It should be noted there are many other cities throughout the Western Hemisphere that are themselves Santiago even if it doesn’t features in their short more popular name.
For example, Querétaro, Mexico full name is actually Santiago de Querétaro. Cali in Colombia is actually Santiago de Chile. Guayaquil in Ecuador is actually Santiago de Guayaquil. Caracas, the capital of Venezuela, is actually Santiago de León de Santiago. There are many more.
Santiago de los Caballeros, Dominican Republic is the first Santiago in the Americas.
For example, Querétaro, Mexico full name is actually Santiago de Querétaro. Cali in Colombia is actually Santiago de Chile. Guayaquil in Ecuador is actually Santiago de Guayaquil. Caracas, the capital of Venezuela, is actually Santiago de León de Santiago. There are many more.
Santiago de los Caballeros, Dominican Republic is the first Santiago in the Americas.